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Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus
- Issue Date
- 1-Feb-2015
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Dictamnus dasycarpus; Rutaceae; Glabretal-type triterpenoid; Antiproliferative effect
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.25, no.3, pp.621 - 625
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 25
- Number
- 3
- Start Page
- 621
- End Page
- 625
- ISSN
- 0960-894X
- Abstract
- Four new glabretal-type triterpenoids, dictabretols A-D (1-4), were isolated by activity-guided fractionation from the root bark of Dictamnus dasycarpus T. (Rutaceae) using an in vitro antiproliferative assay on T cells using splenocytes. The structures of these compounds were determined by spectroscopic methods, including 2D NMR experiments. Compounds were evaluated for their immunosuppressive activity on T cells and demonstrated inhibition of proliferation of activated T cells, up to IC50 of 1.5 mu M. (C) 2014 Elsevier Ltd. All rights reserved.
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Related Researcher
- Lee, Dong ho
- Department of Plant Biotechnology