Effects of the interleukin-1 beta-511 C/T gene polymorphism on the risk of gastric cancer in the context of the relationship between race and H. pylori infection: a meta-analysis of 20,000 subjects
- Authors
- Park, Min-Jeong; Hyun, Myung-Han; Yang, Jong-Pill; Yoon, Jeong-Min; Park, Sungsoo
- Issue Date
- 1월-2015
- Publisher
- SPRINGER
- Keywords
- Interleukin-1beta; IL-1 beta-511; Cytokine; Stomach neoplasm; Single-nucleotide polymorphism
- Citation
- MOLECULAR BIOLOGY REPORTS, v.42, no.1, pp.119 - 134
- Indexed
- SCIE
SCOPUS
- Journal Title
- MOLECULAR BIOLOGY REPORTS
- Volume
- 42
- Number
- 1
- Start Page
- 119
- End Page
- 134
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/94795
- DOI
- 10.1007/s11033-014-3748-7
- ISSN
- 0301-4851
- Abstract
- The interleukin (IL)-1 beta-511 C/T polymorphism has been shown to be functional and to contribute to the risk of gastric cancer. However, the relationship between the IL-1 beta-511 C/T polymorphism and gastric carcinogenesis remains inconclusive. A systematical electronic search was conducted of the MEDLINE, EMBASE, and CENTRAL databases. A random and a fixed effects model were exploited to estimate summary odds ratios and 95 % confidence intervals. Subgroup and sensitivity analyses were carried out with respect to ethnicity, quality assessment scores, control sources, genotyping methods, cancer histopathology and location, and Helicobacter pylori (H. pylori) infection. A total of 45 studies containing 9,066 cases of gastric cancer and 11,192 control subjects satisfied the inclusion criteria. The IL-1 beta-511 C/T polymorphism was found to enhance the risk of stomach cancer for overall and HWE-satisfying studies. Asians showed a positive relationship in both the overall and HWE-satisfying groups, whereas Caucasians did not. Based on subgroup analysis, H. pylori infection and genotype analysis using PCR-RFLP methods increase the association between IL-1 beta-511 T allele carrier and risk of stomach cancer. A positive relationship was found between the IL-1 beta-511 C/T SNP and stomach carcinoma susceptibility, and the results suggest that Asian ethnicity, H. pylori infection and methodologically, PCR-RFLP genotyping strengthen this relationship. Reflecting on prevalence of H. pylori in Asian countries, additional studies on the IL-1 beta-511 C/T SNP in the context of ethnicity and H. pylori infection may provide key insights into the mechanism underlying gastric cancer carcinogenesis. It was found PCR-RFLP is the most reliable genotyping method, and thus, it is recommendable to adopt it to determine the presence of the IL-1 beta-511 C/T SNP.
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