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Biotin-guided anticancer drug delivery with acidity-triggered drug release
- Issue Date
- 2015
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- CHEMICAL COMMUNICATIONS, v.51, no.45, pp.9343 - 9345
- Indexed
- SCIE
SCOPUS
- Journal Title
- CHEMICAL COMMUNICATIONS
- Volume
- 51
- Number
- 45
- Start Page
- 9343
- End Page
- 9345
- ISSN
- 1359-7345
- Abstract
- A novel biotin-guided anticancer drug delivery system, prodrug 9, consisting of biotin, nitrobenzene, and doxorubicin, with acid-triggered drug releasing capability was synthesized. Its cellular uptake and anticancer activity are selective to the HepG2 cell line over the WI-38 cell line, as revealed by fluorescence confocal microscopic experiments and MTT assay.
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Collections - College of Science > Department of Chemistry > 1. Journal Articles
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