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Behavioral changes of zebrafish according to cisplatin-induced toxicity of the balance system

Authors
Kim, M. J.Choi, J.Kim, N.Han, G. C.
Issue Date
11월-2014
Publisher
SAGE PUBLICATIONS LTD
Keywords
Zebrafish; cisplatin; toxicity; vestibule of ear; behavior
Citation
HUMAN & EXPERIMENTAL TOXICOLOGY, v.33, no.11, pp.1167 - 1175
Indexed
SCIE
SCOPUS
Journal Title
HUMAN & EXPERIMENTAL TOXICOLOGY
Volume
33
Number
11
Start Page
1167
End Page
1175
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/96852
DOI
10.1177/0960327114521046
ISSN
0960-3271
Abstract
Background and objectives: Zebrafish are commonly used as experimental animals in otolaryngology studies. However, the behavioral characteristics of these fish are not well known, especially those related to the vestibular system. The goal of this study was to evaluate behavioral changes in zebrafish due to toxicity in the balance system. Materials and methods: Zebrafish were exposed to 1000 M cisplatin for 6 h. We, then, periodically monitored swimming depth, total swimming distance, peak swimming velocity, and mean swimming velocity of the fish for approximately 21 days. Results: Total swimming distance (p < 0.0001), peak swimming velocity (p = 0.0063), and mean swimming velocity (p < 0.0001) in the cisplatin-administered group were significantly decreased when compared with control fish. Conclusion: Our findings demonstrate that cisplatin can alter the locomotion behavior of zebrafish.
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