Chemokine receptor 5 Delta 32 polymorphism and systemic lupus erythematosus, vasculitis, and primary Sjogren's syndrome Meta-analysis of possible associations

Abstract

Objective. The aim of this study was to determine whether the functional chemokine receptor 5 delta32 (CCR5-Delta 32) polymorphism is associated with susceptibility to systemic lupus erythematosus (SLE), vasculitis, and primary Sjogren's syndrome (pSS). Results. A total of 12 studies were analyzed, including 5 on SLE, 5 on vasculitis, and 2 on pSS, encompassing 1881 patients and 2391 controls. Meta-analysis indicated no association between SLE and the CCR5-Delta 32 allele (OR 0.842, 95% CI 0.793-1.804, p= 0.657), and no association between the CCR5-Delta 32 allele and SLE in Europeans (OR 0.647, 95% CI 0.306-1.368, p= 0.255). Meta-analysis of the CCR5-Delta 32 allele and the Delta 32 Delta 32+Delta 32 W genotype showed no association with lupus nephritis (LN; OR 1.771, 95% CI 0.4756.595, p= 0.395; OR 2.192, 95% CI 0.18226.42, p= 0.537, respectively). In addition, meta- analysis revealed no association between the CCR5-Delta 32 allele and vasculitis in all study subjects and in Europeans (OR 1.241, 95% CI 0.951-1.620, p= 0.111; OR 1.359, 95% CI 0.803-2.303, p= 0.254, respectively). However, the overall OR for the CCR5-Delta 32 allele was significantly higher in Kawasaki disease (KD; OR 1.746, 95% CI 1.003-2.955, p= 0.038) and the meta-analysis of the Delta 32 Delta 32+Delta 32 W genotype showed a trend indicating an association with KD (OR 1.683, 95% CI 0.9213.077, p= 0.091). No association was found between the CCR5-Delta 32 polymorphism and pSS. Conclusion. This meta-analysis demonstrates that the CCR5-Delta 32 polymorphism is associated with KD, but does not facilitate susceptibility to SLE, LN, or pSS.