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Escitalopram Efficacy in Depression A Cross-Ethnicity Examination of the Serotonin Transporter Promoter Polymorphism
- Authors
- Bousman, Chad A.; Sarris, Jerome; Won, Eun-Soo; Chang, Hun-Soo; Singh, Ajeet; Lee, Hwa-Young; Ham, Byung-Joo; Tan, Chay-Hoon; Lee, Min-Soo; Ng, Chee H.
- Issue Date
- 10월-2014
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- antidepressant; genotype; pharmacogenetic; efficacy
- Citation
- JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, v.34, no.5, pp.645 - 648
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
- Volume
- 34
- Number
- 5
- Start Page
- 645
- End Page
- 648
- ISSN
- 0271-0749
- Abstract
- Current evidence suggests that polymorphism in the serotonin transporter gene (5-HTTLPR) predicts antidepressant efficacy in whites but less so in Asians. However, it is not clear whether this effect can be observed for specific types of antidepressant drugs. White (n = 47) and Korean (n = 118) participants with major depressive disorder were treated with escitalopram and assessed over 8 weeks. Among those with the l/l but not l/s or s/s genotypes, whites had greater depression score reductions, response rates, and remission rates compared with Koreans. Our results suggest that 5-HTTLPR predicts escitalopram efficacy in an ethnicity-dependent manner.
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