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Escitalopram Efficacy in Depression A Cross-Ethnicity Examination of the Serotonin Transporter Promoter Polymorphism

Authors
Bousman, Chad A.Sarris, JeromeWon, Eun-SooChang, Hun-SooSingh, AjeetLee, Hwa-YoungHam, Byung-JooTan, Chay-HoonLee, Min-SooNg, Chee H.
Issue Date
10월-2014
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Keywords
antidepressant; genotype; pharmacogenetic; efficacy
Citation
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, v.34, no.5, pp.645 - 648
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
Volume
34
Number
5
Start Page
645
End Page
648
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/97324
DOI
10.1097/JCP.0000000000000165
ISSN
0271-0749
Abstract
Current evidence suggests that polymorphism in the serotonin transporter gene (5-HTTLPR) predicts antidepressant efficacy in whites but less so in Asians. However, it is not clear whether this effect can be observed for specific types of antidepressant drugs. White (n = 47) and Korean (n = 118) participants with major depressive disorder were treated with escitalopram and assessed over 8 weeks. Among those with the l/l but not l/s or s/s genotypes, whites had greater depression score reductions, response rates, and remission rates compared with Koreans. Our results suggest that 5-HTTLPR predicts escitalopram efficacy in an ethnicity-dependent manner.
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