Antihyperlipidemic Effects of Rhapontin and Rhapontigenin from Rheum undulatum in Rats Fed a High-Cholesterol Diet
- Authors
- Jo, Sung-Pil; Kim, Jeong-Keun; Lim, Young-Hee
- Issue Date
- 8월-2014
- Publisher
- GEORG THIEME VERLAG KG
- Keywords
- Rheum undulatum; Polygonaceae; methoxylated stilbene; antihyperlipidemic effect; high-cholesterol diet
- Citation
- PLANTA MEDICA, v.80, no.13, pp.1067 - 1071
- Indexed
- SCIE
SCOPUS
- Journal Title
- PLANTA MEDICA
- Volume
- 80
- Number
- 13
- Start Page
- 1067
- End Page
- 1071
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/97750
- DOI
- 10.1055/s-0034-1382999
- ISSN
- 0032-0943
- Abstract
- Rhapontin was purified from a methanol extract from the roots of Rheum undulatum, and rhapontigenin was produced by an enzymatic transformation of rhapontin. Rats were fed a high-cholesterol diet to induce hyperlipidemia, followed by oral treatment with rhapontin or rhapontigenin (1-5 mg/kg/day). Rhapontin and rhapontigenin treatment resulted in a significant (p < 0.05) dose-dependent decrease in the serum lipid level, while the high-density lipoprotein cholesterol level increased slightly compared with the experimental control. Furthermore, rhapontin and rhapontigenin treatment improved the pathological characteristics of the degenerating fatty liver in high-cholesterol diet-induced hyperlipidemic rats dose-dependently. Aspartate aminotransferase and alanine aminotransferase levels in rhapontin- and rhapontigenin-treated hyperlipidemic rats were not significantly different from those in the control. These results indicate that rhapontin and rhapontigenin can be used as potent antihyperlipidemic agents.
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Collections - College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles
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