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Immune-mediated tumor evolution: Nanog links the emergence of a stem like cancer cell state and immune evasion
- Authors
- Mao, Chih-Ping; Wu, T. C.; Song, Kwon-Ho; Kim, Tae Woo
- Issue Date
- Jul-2014
- Publisher
- TAYLOR & FRANCIS INC
- Keywords
- cytotoxic T lymphocytes; immune-resistant; immune surveillance; Nanog; stem-like phenotype
- Citation
- ONCOIMMUNOLOGY, v.3, no.7
- Indexed
- SCIE
SCOPUS
- Journal Title
- ONCOIMMUNOLOGY
- Volume
- 3
- Number
- 7
- ISSN
- 2162-4011
- Abstract
- Tumor cells undergo molecular evolution under immune pressure. Using a murine metastatic lung cancer model, we recently reported that evolutionary pressure enforced through vaccination incites gain of Nanog, a master transcription factor that mediates both emergence of a stem-like cancer cell state and immune evasion. Thus, therapeutic strategies aiming to blunt NANOG's expression in patient tumors may improve the clinical management of cancer.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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