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Salmonella typhimurium with gamma-radiation induced H(2)AX phosphorylation and apoptosis in melanoma
- Issue Date
- 6월-2014
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- H2A histone family member (H(2)AX); melanoma; radiotherapy; reactive oxygen species (ROS); Salmonella typhimurium
- Citation
- BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.78, no.6, pp.1082 - 1085
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
- Volume
- 78
- Number
- 6
- Start Page
- 1082
- End Page
- 1085
- ISSN
- 0916-8451
- Abstract
- To investigate the combinatorial effects using Salmonella and gamma-radiation, the Salmonella typhimurium infection in combination with gamma-radiation was investigated on melanoma. We showed that ROS expression and H(2)AX phosphorylation increased during stress by gamma-radiation irrespective of Salmonella infection, inducing apoptosis by caspase-3 and bcl2 in tumor cells. In addition, tumor growth was suppressed by this combinatory therapy suggesting candidates for radiation therapy against melanoma.
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