Immunomodulatory Effects of Balneotherapy with Hae-Un-Dae Thermal Water on Imiquimod-Induced Psoriasis-Like Murine Model
- Authors
- Lee, Young Bok; Lee, Jun Young; Lee, Hye Jin; Yun, Seong Taek; Lee, Jong Tae; Kim, Hong Jig; Yu, Dong Soo; Woo, So Youn; Kim, Jin-Wou
- Issue Date
- 4월-2014
- Publisher
- KOREAN DERMATOLOGICAL ASSOC
- Keywords
- Bath; Immunomodulation; Mineral waters; Psoriasis
- Citation
- ANNALS OF DERMATOLOGY, v.26, no.2, pp.221 - 230
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- ANNALS OF DERMATOLOGY
- Volume
- 26
- Number
- 2
- Start Page
- 221
- End Page
- 230
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/98891
- DOI
- 10.5021/ad.2014.26.2.221
- ISSN
- 1013-9087
- Abstract
- Background: Balneotherapy, although not a well-established dermatological treatment, is thought to have therapeutic properties for psoriasis and is used as an alternative treatment modality throughout the world. Objective: To evaluate the mechanism underlying the therapeutic immunologic effects of thermomineral water. Methods: A murine model of imiquimod-induced psoriasis-like skin inflammation was used for evaluating the therapeutic effects of balneotherapy with Hae-Un-Dae hot spring mineral water. The clinical improvements were evaluated by a dermatologist. Lesional cytokines, including interleukin (IL)-17A, IL-23, and IL-22, were quantitatively measured by real-time reverse transcriptase polymerase chain reaction. Serum levels of interferon-gamma, IL-4, IL-5, and IL-17A were measured by enzyme- linked immunosorbent assay. T cell proportions in the spleen were evaluated by flow cytometry, and histopathological evaluation of the skin was also performed. Results: The mineral water balneotherapy group showed faster improvement in skin erythema and scales than the distilled water bathing group. A substantial reduction was observed in the lesional mRNA levels of IL-17A and IL-23 in the mineral water group. Serum levels of IL-4 and IL-5 were significantly decreased in the mineral water group but hot in the distilled water group. Normalized T cell proportions were observed after bathing. Conclusion: Balneotherapy showed immunomodulatory effects in a psoriasis-like murine model. Balneotherapy suppressed lesional IL-23 and IL-17A, which are important cytokines in the pathogenesis of psoriasis. These results suggest that balneotherapy can be used as an effective and safe treatment for psoriasis.
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