IgA(+)plasma cells in murine intestinal lamina propria as a positive regulator of T-reg differentiation
- Authors
- Kim, Myun Soo; Kim, Tae Sung
- Issue Date
- Mar-2014
- Publisher
- FEDERATION AMER SOC EXP BIOL
- Keywords
- Foxp3; regulatory T cell; TGF-; retinoic acid
- Citation
- JOURNAL OF LEUKOCYTE BIOLOGY, v.95, no.3, pp.461 - 469
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF LEUKOCYTE BIOLOGY
- Volume
- 95
- Number
- 3
- Start Page
- 461
- End Page
- 469
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/99133
- DOI
- 10.1189/jlb.0613310
- ISSN
- 0741-5400
- Abstract
- IgA(+) plasma cells from murine small intestinal lamina propria induce Foxp3 expression in CD4(+)CD25(-) T cells via TGF- and retinoic acid. Continuous exposure to commensal bacteria gives rise to a complex intestinal immune system that maintains local tolerance, which requires Foxp3-expressing T-reg. Recently, the regulation of T-FH function by plasma cells has been reported, but effects of intestinal LP-PCs, one of the richest plasma cells in the body, on T cell differentiation have not been studied. Here, we investigated whether IgA(+) LP-PCs from murine small intestines had effects on T cell differentiation. Surprisingly, when IgA(+) LP-PCs were cocultured with CD4(+) T cells, Foxp3 expression was increased significantly in CD4(+)CD25(-) T cells. Results using the Transwell coculture system revealed that soluble factors from LP-PCs, TGF-, and RA were involved in the induction of Foxp3 expression. Furthermore, Foxp3(+)CD25(-) T cells were decreased in PP after intestinal depletion of plasma cells. In addition, intestinal colony transfer from SPF to germ-free mice was demonstrated to generate IgA(+) LP-PCs and Foxp3(+) T cells with meaningful correlation in LP. We report for the first time that IgA(+) LP-PCs induce Foxp3 expression in T cells through TGF- and RA. LP-PCs generated by commensal bacteria may play a crucial role in intestinal immunity through the induction of T-reg, as well as IgA production.
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