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Hippocampal and cortical atrophy in amyloid-negative mild cognitive impairments: comparison with amyloid-positive mild cognitive impairment

Authors
Ye, Byoung SeokSeo, Sang WonKim, Chi HunJeon, SeunKim, Geon HaNoh, YoungCho, HannaYoon, Cindy W.Kim, Hee JinJang, Eun YoungLee, JeongminKim, Jung-HyunChin, JuheeLee, Jong MinKim, Jeong-HunSeong, Joon-kyungKim, Chang-HunChoe, Yearn SeongLee, Kyung HanNa, Duk L.
Issue Date
2월-2014
Publisher
ELSEVIER SCIENCE INC
Keywords
Mild cognitive impairment; Alzheimer' s disease; Pittsburgh compound B; Cortical thickness; Hippocampus
Citation
NEUROBIOLOGY OF AGING, v.35, no.2, pp.291 - 300
Indexed
SCIE
SCOPUS
Journal Title
NEUROBIOLOGY OF AGING
Volume
35
Number
2
Start Page
291
End Page
300
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/99343
DOI
10.1016/j.neurobiolaging.2013.08.017
ISSN
0197-4580
Abstract
Although patients with amnestic mild cognitive impairment (aMCI) are at higher risk of developing Alzheimer's disease (AD), their pathologies could be heterogeneous. We aimed to evaluate structural changes in amyloid-negative and amyloid-positive aMCI patients. Forty-eight aMCI patients who underwent Pittsburgh compound B (PiB) positron emission tomography were recruited. They were classified as PiB (-) aMCI (N = 16) and PiB (+) (N = 32). Hippocampal shape and regional cortical thickness were compared with 41 subjects with normal cognition (NC). Relative to NC, PiB(-) aMCI exhibited hippocampal deformity in the right cornu ammonis 1, whereas PiB(+) aMCI exhibited hippocampal deformity in bilateral subiculum and cornu ammonis 1 subregions. Relative to NC, PiB(-) aMCI showed cortical thinning in the left medial prefrontal and right anterior temporal regions, whereas PiB(+) aMCI exhibited cortical thinning in bilateral medial temporal regions, temporoparietal junctions and precuneus, and prefrontal cortices. Our findings suggest that structural changes in PiB(-) aMCI might be due to several possible pathologic changes, whereas structural changes in PiB(+) aMCI reflect AD-like structural changes. (C) 2014 Elsevier Inc. All rights reserved.
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