YAP and TAZ Regulate Skin Wound Healing
- Authors
- Lee, Min-Jung; Byun, Mi Ran; Furutani-Seiki, Makoto; Hong, Jeong-Ho; Jung, Han-Sung
- Issue Date
- 2월-2014
- Publisher
- ELSEVIER SCIENCE INC
- Citation
- JOURNAL OF INVESTIGATIVE DERMATOLOGY, v.134, no.2, pp.518 - 525
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Volume
- 134
- Number
- 2
- Start Page
- 518
- End Page
- 525
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/99401
- DOI
- 10.1038/jid.2013.339
- ISSN
- 0022-202X
- Abstract
- The Hippo signaling pathway regulates organ size, tissue regeneration, and stem cell self-renewal. The two key downstream transcription coactivators in this pathway, Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ), mediate the major gene regulation and biological functions of the Hippo pathway. The biological functions of YAP and TAZ in many tissues are known; however, their roles in skin wound healing remain unclear. To analyze whether YAP and/or TAZ are required for cutaneous wound healing, we performed small interfering RNA (siRNA)-mediated knockdown of YAP/TAZ in full-thickness skin wounds. YAP is strongly expressed in the nucleus and cytoplasm in the epidermis and hair follicle. Interestingly, YAP is expressed in the nucleus in the dermis at 2 and 7 days after wounding. TAZ normally localizes to the cytoplasm in the dermis but is distributed in both the nucleus and cytoplasm at 1 day after wounding. The knockdown of YAP and TAZ markedly delayed the rate of wound closure and reduced the transforming growth factor-beta 1 (TGF-beta 1) expression in the wound. YAP and TAZ also modulate the expression of TGF-beta 1 signaling pathway components such as Smad-2, p21, and Smad-7. These results suggest that YAP and TAZ localization to the nucleus is required for skin wound healing.
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Collections - Graduate School > Department of Life Sciences > 1. Journal Articles
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