Anti-obesity efficacy of nanoemulsion oleoresin capsicum in obese rats fed a high-fat diet
- Authors
- Kim, Joo-Yeon; Lee, Mak-Soon; Jung, Sunyoon; Joo, Hyunjin; Kim, Chong-Tai; Kim, In-Hwan; Seo, Sangjin; Oh, Soojung; Kim, Yangha
- Issue Date
- 2014
- Publisher
- DOVE MEDICAL PRESS LTD
- Keywords
- oleoresin capsicum; nanoemulsion; anti-obesity; gene expression; AMP-activated protein kinase; rats
- Citation
- INTERNATIONAL JOURNAL OF NANOMEDICINE, v.9, pp.301 - 310
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF NANOMEDICINE
- Volume
- 9
- Start Page
- 301
- End Page
- 310
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/101125
- DOI
- 10.2147/IJN.S52414
- ISSN
- 1176-9114
- Abstract
- Purpose: This study determined the effects of oleoresin capsicum (OC) and nanoemulsion OC (NOC) on obesity in obese rats fed a high-fat diet. Methods: The rats were randomly separated into three groups: a high-fat (HF) diet group, HF + OC diet group, and HF + NOC diet group. All groups were fed the diet and water ad libitum for 14 weeks. Results: NOC reduced the body weight and adipose tissue mass, whereas OC did not. OC and NOC reduced mRNA levels of adipogenic genes, including peroxisome proliferator-alpha ctivated receptor (PPAR)-gamma, sterol regulatory element-binding protein-1c, and fatty acid-binding protein in white adipose tissue. The mRNA levels of genes related to beta-oxidation or thermogenesis including PPAR-alpha, palmitoyltransferase-1 alpha, and uncoupling protein-2 were increased by the OC and NOC relative to the HF group. Both OC and NOC clearly stimulated AMP-alpha ctivated protein kinase (AMPK) activity. In particular, PPAR-alpha, palmitoyltransferase-1 alpha, uncoupling protein-2 expression, and AMPK activity were significantly increased in the NOC group compared to in the OC group. NOC decreased glycerol-3-phosphate dehydrogenase activity whereas OC did not. Conclusion: From these results, NOC could be suggested as a potential anti-obesity agent in obese rats fed a HF diet. The effects of the NOC on obesity were associated with changes of multiple gene expression, activation of AMPK, and inhibition of glycerol-3-phosphate dehydrogenase in white adipose tissue.
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Collections - College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles
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