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Inhibitory constituents of the heartwood of Dalbergia odorifera on nitric oxide production in RAW 264.7 macrophages
- Authors
- Lee, Chul; Lee, Jin Woo; Jin, Qinghao; Jang, Dae Sik; Lee, Sung-Joon; Lee, Dongho; Hong, Jin Tae; Kim, Youngsoo; Lee, Mi Kyeong; Hwang, Bang Yeon
- Issue Date
- 15-7월-2013
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Dalbergia odorifera; Leguminosae; Isoflavonoid; Nitric oxide; (2S)-Pinocembrin
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.23, no.14, pp.4263 - 4266
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 23
- Number
- 14
- Start Page
- 4263
- End Page
- 4266
- ISSN
- 0960-894X
- Abstract
- Two new isoflavanones (1 and 13), along with 25 known compounds (2-12, 14-27), were isolated from the EtOAc-soluble fraction of the heartwood of Dalbergia odorifera by following their potential to inhibit the LPS-induced nitric oxide production in RAW 264.7 cells. The structures of the isolated compounds were established by spectroscopic data such as D-1, D-2 NMR and MS spectrometry. Among the isolated compounds, (2S)-pinocembrin (26), showed the most potent inhibitory effect with IC50 value of 18.1 mu M. (C) 2013 Elsevier Ltd. All rights reserved.
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