Inhibitory effect of chaga mushroom extract on compound 48/80-induced anaphylactic shock and IgE production in mice
- Authors
- Yoon, Taek Joon; Lee, Sue Jung; Kim, Eun Young; Cho, Eun Hee; Kang, Tae Bong; Yu, Kwang-Won; Suh, Hyung Joo
- Issue Date
- 4월-2013
- Publisher
- ELSEVIER
- Keywords
- Inonotus obliquus; Allergy; Anaphylaxis; Ovalbumin; IgE
- Citation
- INTERNATIONAL IMMUNOPHARMACOLOGY, v.15, no.4, pp.666 - 670
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL IMMUNOPHARMACOLOGY
- Volume
- 15
- Number
- 4
- Start Page
- 666
- End Page
- 670
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/103664
- DOI
- 10.1016/j.intimp.2013.03.015
- ISSN
- 1567-5769
- Abstract
- Chaga mushrooms (Inonotus obliquus) are hypothesised to exhibit general immune-potentiating, anti-inflammatory, and antitumor properties, but their anti-allergic activities are not fully understood. Therefore, this study investigated whether a chaga mushroom extract (C-HE) might have anti-allergic activity. This activity was assessed through the levels of the IgE Ab produced in response to an allergen (OVA). The administration of C-HE prophylactically inhibited the systemic anaphylactic shock induced by compound 48/80 in mice. The oral administration of C-HE significantly reduced the total IgE levels in mice and slightly affected the production of IgG1. Furthermore, spleen cell cultures harvested from OVA-sensitised mice that had received C-HE orally showed a significant increase in Th1-derived responses (IFN-gamma production). Therefore, our results suggest that the chaga mushroom extract may be used as an anti-allergic functional food. (c) 2013 Published by Elsevier B.V.
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Collections - College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles
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