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Acetylenic acid analogues from the edible mushroom Chanterelle (Cantharellus cibarius) and their effects on the gene expression of peroxisome proliferator-activated receptor-gamma target genes
- Authors
- Hong, Seong Su; Lee, Ji Hae; Jeong, Wonsik; Kim, Nahyun; Jin, Hui Zi; Hwang, Bang Yeon; Lee, Hak-Ju; Lee, Sung-Joon; Jang, Dae Sik; Lee, Dongho
- Issue Date
- 15-Mar-2012
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Chanterelle; Cantharellus cibarius; Peroxisome proliferator-activated receptor (PPAR)-gamma agonist; Acetylenic acid
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.22, no.6, pp.2347 - 2349
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 22
- Number
- 6
- Start Page
- 2347
- End Page
- 2349
- ISSN
- 0960-894X
- Abstract
- A new acetylenic acid, (10E, 14Z)-9-oxooctadeca-10,14-dien-12-ynoicacid (1), was isolated from the edible mushroom Chanterelle (Cantharellus cibarius), together with a known acetylenic acid, (10E, 14Z)-9-hydroxyoctadeca-10,14-dien-12-ynoic acid (2) and their structures were determined through analysis of NMR and mass data. The new acetylenic acid (1) specifically activated peroxisome proliferator-activated receptor (PPAR)-gamma with an EC50 value of 1.88 mu M as measured by a reporter gene assay. Expression of PPAR-gamma target genes were significantly altered as well, supporting the hypothesis that compound 1 is a PPAR-gamma potential agonist that regulates transcription of the PPAR-gamma target genes. (C) 2012 Elsevier Ltd. All rights reserved.
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Related Researcher
- Lee, Sung Joon
- College of Life Sciences and Biotechnology (Division of Food Bioscience and Technology)