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Nanoemulsified green tea extract shows improved hypocholesterolemic effects in C57BL/6 mice

Authors
Kim, Young JunHoung, Soung-JinKim, Jae HoonKim, Young-RokJi, Hong GeunLee, Sung-Joon
Issue Date
2월-2012
Publisher
ELSEVIER SCIENCE INC
Keywords
Antioxidant; Bioavailability; Green tea; Hypolipidemia; Nanoemulsification
Citation
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, v.23, no.2, pp.186 - 191
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
Volume
23
Number
2
Start Page
186
End Page
191
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/106157
DOI
10.1016/j.jnutbio.2010.11.015
ISSN
0955-2863
Abstract
Nanoemulsification of nutrients could improve bioavailability by enhancing intestinal uptake. We investigated the antioxidant and hypolipidemic effects of nanoemulsified green tea extract (NGTE). Antioxidant effect was measured by 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging assay and dichlorofluorescein diacetate (DCFH-DA) assay. C57BL/6 mice were fed a control high-fat diet, green tea extract (GTE). or NGTE diet for 4 weeks. In composition analysis, GTE and NGTE contained similar total catechin concentrations. The antioxidative effect of GTE was comparable with that of NGTE. In the ABTS assay, GTE had a marked effect, although NGTE was more effective than GTE in the DCFH-DA assay. In the mouse feeding experiment, total and low-density lipoprotein (LDL) cholesterol concentrations were significantly reduced after NGTE treatment in comparison with GTE treatment in high-fat-fed C57BL/6J mice over the course of 4 weeks. The hypocholesterolemic effects were greater in the NGTE group compared with the GTE group (24% vs. 15.4% LDL cholesterol reduction compared with the control). Expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase was significantly down-regulated. Protein expression of LDL receptor was significantly increased in the livers of both the GTE- and NGTE-treated groups (+234.1%, P<.01 and +274.7%, P<.001), with a greater effect in the NGTE than in the GTE group. Cholesterol 7 alpha-hydroxylase gene expression was similarly increased in both the GTE and NGTE groups. These results suggest that nanoemulsification significantly increased hypocholesterolemic effects of GTE in vivo due to increased bioavailability. (C) 2012 Elsevier Inc. All rights reserved.
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Lee, Sung Joon
생명과학대학 (식품공학과)
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