Detailed Information
Cited 0 time in 
Cited 0 time in 
Cited 0 time in
Metadata Downloads
Anti-glycation Effect of Gold Nanoparticles on Collagen
- Issue Date
- Feb-2012
- Publisher
- PHARMACEUTICAL SOC JAPAN
- Keywords
- gold nanoparticle; glycation; collagen; dermis; aging
- Citation
- BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.35, no.2, pp.260 - 264
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Volume
- 35
- Number
- 2
- Start Page
- 260
- End Page
- 264
- ISSN
- 0918-6158
- Abstract
- Gold nanoparticles (GNPs) have been reported to exhibit a variety of biological effects including antiinflammatory and anti-oxidant activities. The extent of an in vitro glycation reaction mixture of collagen and glycolaldehyde was assayed to investigate the inhibition of glycolaldehye-derived advanced glycation end products (glycol-AGEs) formation with GNPs in collagen, which is a major protein component of the human dermis. GNP-treated collagen showed significantly less glycation (56.3 +/- 4.2%) than an untreated glycation control. Moreover, GNP-treated glycation in a collagen lattice model significantly decreased the AGEs distribution in the model system. Taken together, these results suggest that GNPs have the potential for use in the prevention of glycation-induced skin aging.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Related Researcher
- Lee, Kwang Won
- Department of Biotechnology