Effects of Yeast Hydrolysate on Hepatic Lipid Metabolism in High-Fat-Diet-Induced Obese Mice: Yeast Hydrolysate Suppresses Body Fat Accumulation by Attenuating Fatty Acid Synthesis
- Authors
- Jung, Eun Young; Hong, Yang-Hee; Kim, Jae Hwan; Park, Yooheon; Bae, Song Hwan; Chang, Un Jae; Suh, Hyung Joo
- Issue Date
- 2012
- Publisher
- KARGER
- Keywords
- Yeast hydrolysate; Ghrelin; Epididymal fat; Glucose-6-phosphate dehydrogenase; Malic enzyme
- Citation
- ANNALS OF NUTRITION AND METABOLISM, v.61, no.2, pp.89 - 94
- Indexed
- SCIE
SCOPUS
- Journal Title
- ANNALS OF NUTRITION AND METABOLISM
- Volume
- 61
- Number
- 2
- Start Page
- 89
- End Page
- 94
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/109414
- DOI
- 10.1159/000338441
- ISSN
- 0250-6807
- Abstract
- Aims: We observed whether the anti-obesity activity of yeast hydrolysate (YH) was due to the alteration of lipid-regulating enzyme activities. Methods: Male ICR mice were divided into four groups: a normal diet group (ND; 4.2% fat), a high-fat diet group (HF; 27.7% fat), an HF group treated orally with 0.5% or 1% YH in the drinking water (HF+YH0.5; 27.7% fat and HF+YH1; 27.7% fat). Results: After 5 weeks, the YH groups (HF+YH0.5 = 3.92 +/- 0.17 g/100 g BW and HF+YH1 = 3.76 +/- 0.13 g/100 g BW) had significantly lower levels of epididymal fats compared to the HF group (4.91 +/- 0.29 g/100 g BW; p<0.05). YH supplementation produced a decrease in serum triglycerides and low-density lipoprotein cholesterol concentrations and body weight gain, and produced a dose-dependent significant increase in serum ghrelin compared with the HF group (p<0.05). Hepatic glucose-6-phosphate dehydrogenase (G6PD) activity was inhibited by YH supplementation compared with the HF group, and mice treated orally with 1% YH exhibited a significant decrease in hepatic malic enzyme (ME) activity compared to obese mice treated with the vehicle (HF = 10.44 +/- 2.74 nmol/min/mg protein vs. HF+YH1 = 6.68 +/- 2.23 nmol/min/mg protein; p<0.05). Conclusions: YH supplementation suppressed body fat accumulation by attenuating fatty acid synthesis through the downregulation of hepatic G6PD and ME activities. Copyright (C) 2012 S. Karger AG, Basel
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Collections - College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles
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