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Novel Tripeptides with alpha-Glucosidase Inhibitory Activity Isolated from Silk Cocoon Hydrolysate
- Issue Date
- 9-Nov-2011
- Publisher
- AMER CHEMICAL SOC
- Keywords
- cocoon; silk peptide E5K6; diabetes; alpha glucosidase
- Citation
- JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.59, no.21, pp 11522 - 11525
- Pages
- 4
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Volume
- 59
- Number
- 21
- Start Page
- 11522
- End Page
- 11525
- ISSN
- 0021-8561
- Abstract
- Active compounds with antidiabetic potential were isolated from silk peptide E5K6 by consecutive ultrafiltration and gel filtration using Biogel P-2 and RS-HPLC using a YMC-Pack Pro C18 column. The highest alpha-glucosidase inhibitory activity of silk peptide E5K6 resulted from fractions With MW <1 kDa. The activities of,gel-filtered fractions from silk peptide E5K6 of <1 kDa were assayed in vitro, demonstrating that the fourth peak (F4) had the highest alpha-glucosidase inhibitory activity (IC(50) = 37 1 mg/mL) F4 of silk peptide E5K6 was separated by HPLC into two peaks Moreover, the purified compounds were identified as Gly-Glu-Tyr (GEY, MW = 367 Da) and Gly-Tyr Gly (GYG, MW = 295 Da) according to amino acid sequences, and their alpha glucosidase inhibitory activities (IC(50)) were 2 7 and 1 5 mg/mL, respectively
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Related Researcher
- Suh, Hyung Joo
- College of Health Sciences (School of Biosystems and Biomedical Sciences)