Transformation of Ginsenoside-rich Fraction Isolated from Ginseng (Panax ginseng) Leaves Induces Compound K
- Authors
- Kim, Sang Hyek; Kim, Seong Yeong; Lee, Ho; Ra, Kyung Soo; Suh, Hyung Joo; Kim, Sun Young; Shin, Kwang-Soon
- Issue Date
- 11월-2011
- Publisher
- KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
- Keywords
- ginseng leaf; ginsenoside-rich fraction; transformation; absorbable metabolite; Compound K
- Citation
- FOOD SCIENCE AND BIOTECHNOLOGY, v.20, no.5, pp.1179 - 1186
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- FOOD SCIENCE AND BIOTECHNOLOGY
- Volume
- 20
- Number
- 5
- Start Page
- 1179
- End Page
- 1186
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/111218
- DOI
- 10.1007/s10068-011-0163-x
- ISSN
- 1226-7708
- Abstract
- To develop the new physiologically active materials from ginseng (Panax ginseng C. A. Meyer) leaves, the ginsenoside-rich fraction (GL-1) was isolated and transformed into highly absorbable metabolites in the gastrointestinal (GI) tract. To transform the ginsenosides in GL-1 into deglycosylated ginsenosides, GL-1 was treated with organic acids (0.1 and 1% lactic and acetic acid solutions) and fermented with isolated strains (P1-P4, and M3) from red ginseng extract for 7 days. The treatment of 0.1% lactic acid of GL-1 induced the highest transforms of partially-deglycosylated ginsenosides such as Mc, F2, and Rg3 (intermediate metabolites). On the other hand, Compound K (Compd K, final metabolite) contents in GL1 ferments with strain M3 showed about 6-time higher than that of control (not fermented). Consequently, the strain M3 was finally selected for the mass production of Compd K with well-absorbable property in GI tract and physiological activity.
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