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Ursolic acid is a PPAR-alpha agonist that regulates hepatic lipid metabolism
- Authors
- Jia, Yaoyao; Bhuiyan, Muhammad Javidul Haque; Jun, Hee-jin; Lee, Ji Hae; Hoang, Minh Hien; Lee, Hak-Ju; Kim, Nahyun; Lee, Dongho; Hwang, Kwang Yeon; Hwang, Bang Yeon; Choi, Dal-Woong; Lee, Sung-Joon
- Issue Date
- 1-Oct-2011
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Ursolic acid; PPAR-alpha; Agonist; Lipid metabolism; Hepatocyte
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.21, no.19, pp.5876 - 5880
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 21
- Number
- 19
- Start Page
- 5876
- End Page
- 5880
- ISSN
- 0960-894X
- Abstract
- In this study, we confirmed that ursolic acid, a plant triterpenoid, activates peroxisome proliferator-activated receptor (PPAR)-alpha in vitro. Surface plasmon resonance and time-resolved fluorescence resonance energy transfer analyses do not show direct binding of ursolic acid to the ligand-binding domain of PPAR-alpha; however, ursolic acid enhances the binding of PPAR-alpha to the peroxisome proliferator response element in PPAR-alpha-responsive genes, alters the expression of key genes in lipid metabolism, significantly reducing intracellular triglyceride and cholesterol concentrations in hepatocytes. Thus, ursolic acid is a PPAR-alpha agonist that regulates the expression of lipid metabolism genes, but it is not a direct ligand of PPAR-alpha. (C) 2011 Elsevier Ltd. All rights reserved.
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Related Researcher
- Lee, Dong ho
- Department of Plant Biotechnology