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Synthesis of (S)-(+)-decursin and its analogues as potent inhibitors of melanin formation in B16 murine melanoma cells
- Authors
- Lee, Kyeong; Lee, Jee-Hyun; Boovanahalli, Shanthaveerappa K.; Choi, Yongseok; Choo, Soo-Jin; Yoo, Ick-dong; Kim, Dong Hee; Yun, Mi Young; Lee, Gye Won; Song, Gyu-Yong
- Issue Date
- 12월-2010
- Publisher
- ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
- Keywords
- (+)-Decursinol; (+)-Decursin; (+)-Decursinol angelate; Melanin inhibitors
- Citation
- EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.45, no.12, pp.5567 - 5575
- Indexed
- SCIE
SCOPUS
- Journal Title
- EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Volume
- 45
- Number
- 12
- Start Page
- 5567
- End Page
- 5575
- ISSN
- 0223-5234
- Abstract
- We report the synthesis of a novel series of highly potent melanin inhibitors which were obtained through structural modification of an anticancer compound S-(+)-decursinol. The in vitro inhibitory potencies of the newly synthesized compounds were evaluated against alpha-MSH induced melanin production in 816 murine melanoma cells. Among the compounds evaluated, compounds 2, 3, 6b, 7a, 7b, 8a and 8b emerged as highly potent inhibitors of melanin production. Besides, these compounds demonstrated significantly low cytotoxicity. (C) 2010 Elsevier Masson SAS. All rights reserved.
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