Effects of Yeast Hydrolysate on Neuropeptide Y (NPY) and Tryptophan Hydroxylase (TPH) Immunoreactivity in Rats
- Authors
- Jung, Eun Young; Kang, Duk Ho; Suh, Hyung Joo; Chang, Un-Jae
- Issue Date
- May-2009
- Publisher
- WILEY
- Keywords
- yeast hydrolysate; neuropeptide Y; tryptophan hydroxylase; anti-obesity
- Citation
- PHYTOTHERAPY RESEARCH, v.23, no.5, pp.619 - 623
- Indexed
- SCIE
SCOPUS
- Journal Title
- PHYTOTHERAPY RESEARCH
- Volume
- 23
- Number
- 5
- Start Page
- 619
- End Page
- 623
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/120147
- DOI
- 10.1002/ptr.2668
- ISSN
- 0951-418X
- Abstract
- To investigate the appetite regulation mechanism of low and high molecular weight yeast hydrolysate, neuropeptide Y (NPY) and tryptophan hydroxylase (TPH) expressions were analyzed in the brains on rats using immunohistochemical method; normal diet (control), 0.1 g/kg (BY-1) or 1.0 g/kg (BY-2) of yeast hydrolysate below 10 kDa, 0.1 g/kg (AY-1) or 1.0 g/kg (AY-2) of yeast hydrolysate of 10-30 kDa. Body weight gain was lower in the BY-2 (133.0 g) than in the control (150.1 g) (p < 0.05). Triacylglyceride, total cholesterol, and LDL-cholesterol levels were lower in the BY-2 as compared to control, BY-1. and AY-2 (p < 0.05). NPY staining intensities at paraventricular nucleus (PVN) were lower in the BY groups (BY-1: 96.1, BY-2: 88.6) as compared to the control (105.6) and AY groups (AY-1: 110.5, AY-2:114.1) (p < 0.05). NPY expression at lateral hypothalamic area (LHA) was lower in the BY-2 (92.3) than in the control (98.9) (p < 0.05). The BY groups (BY-1: 143.9, BY-2: 154.6) had higher TPH staining intensities at dorsal raphe (DR) than the AY-2 (115.9) (p < 0.05). In conclusion, the results indicate that administering yeast hydrolysate of below 10 kDa to normal diet-fed rats reduced body weight gain and serum lipids by altering NPY and TPH expressions. Copyright (C) 2008 John Wiley & Sons, Ltd.
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