Zeatin Prevents Amyloid beta-Induced Neurotoxicity and Scopolamine-Induced Cognitive Deficits
DC Field | Value | Language |
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dc.contributor.author | Choi, Soo Jung | - |
dc.contributor.author | Jeong, Chang-Ho | - |
dc.contributor.author | Choi, Sung-Gil | - |
dc.contributor.author | Chun, Ji-Yeon | - |
dc.contributor.author | Kim, Young Jun | - |
dc.contributor.author | Lee, JeongMin | - |
dc.contributor.author | Shin, Dong-Hoon | - |
dc.contributor.author | Heo, Ho Jin | - |
dc.date.accessioned | 2021-09-08T18:44:39Z | - |
dc.date.available | 2021-09-08T18:44:39Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2009-04 | - |
dc.identifier.issn | 1096-620X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/120386 | - |
dc.description.abstract | The antioxidative and protective effects of zeatin against amyloid beta-protein (A beta)-induced neurotoxicity were investigated using PC12 cells. Zeatin showed antioxidative and cell protective effects against A beta-induced neurotoxicity. In this study, we also evaluated the effect of zeatin on learning and memory capacity in vivo using ICR mice with amnesia induced by scopolamine (1 mg/kg of body weight). Zeatin, when administered to mice at 4.5 mg/kg of body weight, significantly ameliorated scopolamine-induced amnesia as measured in both the passive avoidance test and Y-maze test. Injecting mice with scopolamine impaired performance on the passive avoidance test (48 +/- 4.5% decrease) and on the Y-maze test (12 +/- 1.3% decrease). In contrast, mice treated with zeatin before scopolamine injections were protected from these changes (5-34% decrease in step-through latency; 1-4% decrease in alternation behavior). The present results suggest a possible chemopreventive role of zeatin in Alzheimer's disease. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MARY ANN LIEBERT, INC | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | IN-VITRO | - |
dc.subject | HIPPOCAMPAL-NEURONS | - |
dc.subject | PEPTIDE | - |
dc.subject | ACETYLCHOLINESTERASE | - |
dc.subject | PROTEIN | - |
dc.subject | CELLS | - |
dc.subject | TOXICITY | - |
dc.subject | ENZYME | - |
dc.title | Zeatin Prevents Amyloid beta-Induced Neurotoxicity and Scopolamine-Induced Cognitive Deficits | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Young Jun | - |
dc.contributor.affiliatedAuthor | Shin, Dong-Hoon | - |
dc.identifier.doi | 10.1089/jmf.2007.0678 | - |
dc.identifier.scopusid | 2-s2.0-67649525158 | - |
dc.identifier.wosid | 000266279000005 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MEDICINAL FOOD, v.12, no.2, pp.271 - 277 | - |
dc.relation.isPartOf | JOURNAL OF MEDICINAL FOOD | - |
dc.citation.title | JOURNAL OF MEDICINAL FOOD | - |
dc.citation.volume | 12 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 271 | - |
dc.citation.endPage | 277 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001342569 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | HIPPOCAMPAL-NEURONS | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordPlus | ACETYLCHOLINESTERASE | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | ENZYME | - |
dc.subject.keywordAuthor | neurotoxicity | - |
dc.subject.keywordAuthor | scopolamine | - |
dc.subject.keywordAuthor | zeatin | - |
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