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Effects of Soy Phytoestrogens on Reference Memory and Neuronal Cholinergic Enzymes in Ovariectomized Rats

Authors
Lee, Yoon-BokLee, Keun-HaSohn, Heon-SooLee, Sung-JoonCho, Kyung-HwanKang, Il-JunKim, Dong-WooShin, Yong KookPai, TongkunHwang, In KooWon, Moo-Ho
Issue Date
Feb-2009
Publisher
MARY ANN LIEBERT, INC
Keywords
acetylcholine esterase; choline acetyltransferase; Morris water maze; ovariectomy; soy phytoestrogens
Citation
JOURNAL OF MEDICINAL FOOD, v.12, no.1, pp 64 - 70
Pages
7
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF MEDICINAL FOOD
Volume
12
Number
1
Start Page
64
End Page
70
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/120640
DOI
10.1089/jmf.2007.0633
ISSN
1096-620X
1557-7600
Abstract
The effects of soy phytoestrogens on Morris water maze (MWM) performance and neuronal cholinergic enzyme activities and immunoreactivity were studied in ovariectomized (OVX) rats. The rats were assigned to four groups fed control diet (CD), 3.9 mg/kg 17 beta-estradiol diet (E2), 263.4 mg/kg soy phytoestrogens diet (SP1), and 526.9 mg/kg soy phytoestrogens diet (SP2). In the MWM task, escape latency and path length were significantly less in the E2 and SP2 groups than in the CD group on the second day. Choline acetyltransferase (ChAT) activity in the cerebral cortex and ChAT immunoreactivity in the diagonal band of Broca were significantly greater in the E2, SP1, and SP2 groups than in the CD group. Acetylcholinesterase activity in the hippocampus in the E2, SP1, and SP2 groups was significantly lower than in the CD group. This study suggests that soy phytoestrogens affect the reference memory and neuronal cholinergic system in OVX rats.
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