Advanced Glycation Endproduct-induced Diabetic Complications
- Authors
- Lee, Hyun-Sun; Hong, Chung-Oui; Lee, Kwang-Won
- Issue Date
- 12월-2008
- Publisher
- KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
- Keywords
- advanced glycation endproduct; diabetes mellitus; diabetic complication; inhibitor; reactive oxygen species (ROS)
- Citation
- FOOD SCIENCE AND BIOTECHNOLOGY, v.17, no.6, pp.1131 - 1138
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- FOOD SCIENCE AND BIOTECHNOLOGY
- Volume
- 17
- Number
- 6
- Start Page
- 1131
- End Page
- 1138
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/122292
- ISSN
- 1226-7708
- Abstract
- Diabetic complications are a leading cause of blindness, renal failure, and nerve damage. Additionally, diabetes-accelerated atherosclerosis leads to increased risk of myocardial infarction, stroke, and limb amputation. At the present time, 4 main molecular mechanisms have been implicated in hyperglyceamia-mediated vascular damage. In particular, advanced glycation endproducts (AGE), which are formed by complex, heterogeneous, sugar-derived protein modifications, have been implicated as a major pathogenic process for diabetic complications. Recently, AGE inhibitors such as aminoguanidin, ALT-946, and pyridoxamine have been reported. Such an integrating paradigm provides a new conceptual framework for future research on diabetes complications and oil discovering drugs to prevent the progression of AGE-induced maladies.
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