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Innate immune stimulation of exo-polymers prepared from Cordyceps sinensis by submerged culture
- Issue Date
- Oct-2008
- Publisher
- SPRINGER
- Keywords
- Cordyceps sinensis; innate immunity; exo-polymer; cytokine; NK cell; tumor metastasis
- Citation
- APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, v.80, no.6, pp.1087 - 1093
- Indexed
- SCIE
SCOPUS
- Journal Title
- APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Volume
- 80
- Number
- 6
- Start Page
- 1087
- End Page
- 1093
- ISSN
- 0175-7598
- Abstract
- After we prepared exo-polymers (EPS) from Cordyceps sinensis by submerged culture, prophylactic intravenous administration (i.v.) of EPS significantly inhibited metastasis in experimental lung metastasis of colon 26-M3.1 carcinoma. Cytotoxicity against Yac-1 tumor cells of natural killer (NK) cell, which was prepared by i.v. of EPS (100 mu g/mouse), significantly augmented 2 days after EPS treatment. When NK cells were depleted by rabbit anti-asialo GM1 serum, even the EPS group totally abolished the inhibitory effect on lung metastasis of colon 26-M3.1 cells. EPS can stimulate innate immune system to inhibit tumor metastasis, and its anti-tumor metastasis is associated with macrophage and NK cell activation.
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Related Researcher
- Suh, Hyung Joo
- College of Health Sciences (School of Biosystems and Biomedical Sciences)