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Melampolides from the leaves of Smallanthus sonchifolius and their inhibitory activity of LPS-induced nitric oxide production
- Authors
- Hong, Seong Su; Lee, Seon A.; Han, Xiang Hua; Lee, Min Hee; Hwang, Ji Sang; Park, Jeong Sook; Oh, Ki-Wan; Han, Kun; Lee, Myung Koo; Lee, Heesoon; Kim, Wook; Lee, Dongho; Hwang, Bang Yeon
- Issue Date
- 2월-2008
- Publisher
- PHARMACEUTICAL SOC JAPAN
- Keywords
- Smallanthus sonchifolius; Asteraccae; yacon; melampolide; sesquiterpene lactone; nitric oxide production inhibitor
- Citation
- CHEMICAL & PHARMACEUTICAL BULLETIN, v.56, no.2, pp.199 - 202
- Indexed
- SCIE
SCOPUS
- Journal Title
- CHEMICAL & PHARMACEUTICAL BULLETIN
- Volume
- 56
- Number
- 2
- Start Page
- 199
- End Page
- 202
- ISSN
- 0009-2363
- Abstract
- Two new melampolide-type sesquiterpene lactones, 8 beta-epoxyangeloyloxy-9 alpha-ethoxy-14-oxo-acanthospermolide (1) and 8 beta-angeloyloxy-9 alpha-ethoxy-14-oxo-acanthospermolide (2), were isolated from the leaves of yacon [Smallanthus sonchifolia (POEPP. et ENDL.) H. Robinson] along with eleven known melampolides, allo-schkuhriolide (3), enhydrin (4), polymatin A (5), fluctuanin (6), 8 beta-angeloyloxy-9 alpha-acetoxy-14-oxo-acanthospermolide (7), 8 beta-angeloyloxy-14-oxo-acanthospermolide (8), 8 beta-methacryloyloxymelampolid-14-oic acid methyl ester (9), uvedalin (10), polymatin B (11), 8 beta-tigloyloxymelampolid-14-oic acid methyl ester (12), and sonchifolin (13). Their structures were established on the basis of spectroscopic evidence including 1D- and 2D-NMR experiments. All isolates were evaluated for inhibition of LPS-induced nitric oxide production in murine macrophage RAW 264.7 cells.
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