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In vitro activity of kaempferol isolated from the Impatiens balsamina alone and in combination with erythromycin or clindamycin against Propionibacterium acnes

Authors
Lim, Young-HeeKim, In-HwanSeo, Jung-Ju
Issue Date
Oct-2007
Publisher
MICROBIOLOGICAL SOCIETY KOREA
Keywords
Propionibacterium acnes; kaempferol; erythromycin; clindamycin; checkerboard test
Citation
JOURNAL OF MICROBIOLOGY, v.45, no.5, pp.473 - 477
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF MICROBIOLOGY
Volume
45
Number
5
Start Page
473
End Page
477
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/125703
ISSN
1225-8873
Abstract
The in vitro antibacterial activity against antibiotic-resistant Propionibacterium acnes of kaempferol isolated from the Impatiens balsamina alone and in combination with erythromycin or clindamycin antibiotics was investigated. The antibiotic combination effect against antibiotic-resistant P. acnes was studied by checkerboard test. Kaempferol and quercetin demonstrated antibacterial activities against P. acnes. Minimum inhibitory concentrations (MICs) for both compounds were <= 32 mu g/ml and <= 64 mu g/ml for clindamycin-sensitive and -resistant P. acnes, respectively. The four combination formulations (kaempferol and either erythromycin or clindamycin; quercetin and either erythromycin or clindamycin) exhibited a synergic inhibition of P. acnes growth. The combination of kaempferol with quercetin showed an indifferent effect. The combination of clindamycin with kaempferol or quercetin showed a greater synergic effect than that of erythromycin with kaempferol or quercetin. Thus, these combinations demonstrated the potential to treat acne.
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College of Health Sciences (School of Biosystems and Biomedical Sciences)
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