In vitro activity of kaempferol isolated from the Impatiens balsamina alone and in combination with erythromycin or clindamycin against Propionibacterium acnes
- Authors
- Lim, Young-Hee; Kim, In-Hwan; Seo, Jung-Ju
- Issue Date
- Oct-2007
- Publisher
- MICROBIOLOGICAL SOCIETY KOREA
- Keywords
- Propionibacterium acnes; kaempferol; erythromycin; clindamycin; checkerboard test
- Citation
- JOURNAL OF MICROBIOLOGY, v.45, no.5, pp.473 - 477
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF MICROBIOLOGY
- Volume
- 45
- Number
- 5
- Start Page
- 473
- End Page
- 477
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/125703
- ISSN
- 1225-8873
- Abstract
- The in vitro antibacterial activity against antibiotic-resistant Propionibacterium acnes of kaempferol isolated from the Impatiens balsamina alone and in combination with erythromycin or clindamycin antibiotics was investigated. The antibiotic combination effect against antibiotic-resistant P. acnes was studied by checkerboard test. Kaempferol and quercetin demonstrated antibacterial activities against P. acnes. Minimum inhibitory concentrations (MICs) for both compounds were <= 32 mu g/ml and <= 64 mu g/ml for clindamycin-sensitive and -resistant P. acnes, respectively. The four combination formulations (kaempferol and either erythromycin or clindamycin; quercetin and either erythromycin or clindamycin) exhibited a synergic inhibition of P. acnes growth. The combination of kaempferol with quercetin showed an indifferent effect. The combination of clindamycin with kaempferol or quercetin showed a greater synergic effect than that of erythromycin with kaempferol or quercetin. Thus, these combinations demonstrated the potential to treat acne.
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Collections - College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles
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