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Bone-protective effects of Lactobacillus plantarum B719-fermented milk product
- Authors
- Lee, Chul Sang; Lee, Sun Ho; Kim, Sae Hun
- Issue Date
- Nov-2020
- Publisher
- WILEY
- Keywords
- Fermented milk; Lactic acid bacteria; Lactobacillus; Probiotics; Microbiology
- Citation
- INTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY, v.73, no.4, pp.706 - 717
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY
- Volume
- 73
- Number
- 4
- Start Page
- 706
- End Page
- 717
- ISSN
- 1364-727X
- Abstract
- The current study aimed to investigate the anti-osteoporotic effects of a Lactobacillus plantarum B719-fermented milk product (FMP-B719). Higher proliferation and mineralisation were observed in FMP-B719-treated MC3T3-E1 mouse pre-osteoblastic cells than those in L. casei ATCC 393-FMP-treated MC3T3-E1 cells. Moreover, FMP-B719 normalised the serum alkaline phosphatase (9.37 +/- 1.92 U/L) and phosphorus (8.28 +/- 0.1 mg/dL) in a rat model of ovariectomy-induced postmenopausal osteoporosis. Furthermore, FMP-B719 normalized the bone volume in the proximal femur and increased the femur strength that was decreased in ovariectomized rats. Hence, the results of this study suggest that FMP-B719 could serve as a potential candidate for the treatment and prevention of postmenopausal osteoporosis.
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Related Researcher
- Kim, Sae Hun
- Department of Biotechnology