Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Chicoric acid mitigates impaired insulin sensitivity by improving mitochondrial function

Authors
Kim, Ji-SunLee, HyunjungJung, Chang HwaLee, Sung-JoonHa, Tae-YoulAhn, Jiyun
Issue Date
2018
Publisher
TAYLOR & FRANCIS LTD
Keywords
Chicoric acid; glucose uptake; diet-induced obesity; insulin resistance; mitochondria
Citation
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.82, no.7, pp.1197 - 1206
Indexed
SCIE
SCOPUS
Journal Title
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume
82
Number
7
Start Page
1197
End Page
1206
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/80911
DOI
10.1080/09168451.2018.1451742
ISSN
0916-8451
Abstract
Mitochondrial dysfunction is associated with insulin resistance. Although chicoric acid (CA) is known to have beneficial effects on insulin sensitivity, the involvement of mitochondrial function has not been elucidated yet. Here, we investigated the effect of CA on insulin resistance and mitochondrial dysfunction. In palmitate-induced insulin-resistant C2C12 myotubes, CA improved impaired glucose uptake and insulin signaling pathways, along with enhanced mitochondrial membrane potential and oxygen consumption. CA treatment in diet-induced obese mice ameliorated glucose tolerance and increased insulin sensitivity. CA treatment also recovered the dysregulated expression of glucose metabolism-related genes in the high-fat-fed mice. CA significantly increased the mitochondrial DNA content, citrate synthase, and ATP content, as well as the expression of genes related to mitochondrial biogenesis and oxidative phosphorylation in the liver and skeletal muscle in high-fat- fed obese mice. These findings suggested that CA attenuates insulin resistance and promotes insulin sensitivity by enhancing mitochondrial function.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Biotechnology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Lee, Sung Joon photo

Lee, Sung Joon
생명과학대학 (식품공학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE