Blood Pressure-Lowering Effects of Alacalase-Hydrolyzed Camellia Seed Hull In Vitro and in Spontaneous Hypertensive Rats
DC Field | Value | Language |
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dc.contributor.author | Lim, Ho-Jeong | - |
dc.contributor.author | Kim, Mi-So | - |
dc.contributor.author | Kim, Da-Som | - |
dc.contributor.author | Kim, Young Jun | - |
dc.contributor.author | Lee, Jin Hyup | - |
dc.contributor.author | Pan, Jeong Hoon | - |
dc.contributor.author | Shin, Eui-Cheol | - |
dc.contributor.author | Kim, Jae Kyeom | - |
dc.date.accessioned | 2021-09-03T04:41:22Z | - |
dc.date.available | 2021-09-03T04:41:22Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-07 | - |
dc.identifier.issn | 1096-620X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/83039 | - |
dc.description.abstract | High blood pressure is one of the major risk factors for various diseases and angiotensin-converting enzyme (ACE) plays a critical role in blood pressure regulation. In our study, the responsive surface methodology was adopted to establish optimal Alcalase-hydrolysis conditions of camellia seed hull against ACE activity. The optimum conditions are hydrolysis temperature of 50.98 degrees C, enzyme/substrate ratio of 2.85%, and hydrolysis pH of 7.12. In an animal feeding study, spontaneously hypertensive rats were treated with either a low or high dose of hydrolyzed Camellia japonica seed cake over 5 weeks. Even though systolic blood pressure was not statistically different, the high dose of C. japonica hydrolysate lowered diastolic blood pressure (106 +/- 4.4mmHg vs. 145 +/- 5.9 mmHg) at the 5th week. A similar trend was also observed in serum ACE activity. Considering that this camellia seed hull is a major resource of this plant, our study provides important data to utilize this plant for both academic and industrial applications. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MARY ANN LIEBERT, INC | - |
dc.subject | RESPONSE-SURFACE METHODOLOGY | - |
dc.subject | INHIBITORS | - |
dc.subject | PEPTIDES | - |
dc.subject | FOOD | - |
dc.subject | CAKE | - |
dc.subject | OIL | - |
dc.title | Blood Pressure-Lowering Effects of Alacalase-Hydrolyzed Camellia Seed Hull In Vitro and in Spontaneous Hypertensive Rats | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Young Jun | - |
dc.contributor.affiliatedAuthor | Lee, Jin Hyup | - |
dc.identifier.doi | 10.1089/jmf.2016.0175 | - |
dc.identifier.scopusid | 2-s2.0-85023746313 | - |
dc.identifier.wosid | 000405098600011 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MEDICINAL FOOD, v.20, no.7, pp.720 - 723 | - |
dc.relation.isPartOf | JOURNAL OF MEDICINAL FOOD | - |
dc.citation.title | JOURNAL OF MEDICINAL FOOD | - |
dc.citation.volume | 20 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 720 | - |
dc.citation.endPage | 723 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002246623 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | RESPONSE-SURFACE METHODOLOGY | - |
dc.subject.keywordPlus | INHIBITORS | - |
dc.subject.keywordPlus | PEPTIDES | - |
dc.subject.keywordPlus | FOOD | - |
dc.subject.keywordPlus | CAKE | - |
dc.subject.keywordPlus | OIL | - |
dc.subject.keywordAuthor | alcalase | - |
dc.subject.keywordAuthor | angiotensin-converting enzyme | - |
dc.subject.keywordAuthor | antihypertensive effect | - |
dc.subject.keywordAuthor | Camellia japonica | - |
dc.subject.keywordAuthor | spontaneously hypertensive rat | - |
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