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Blood Pressure-Lowering Effects of Alacalase-Hydrolyzed Camellia Seed Hull In Vitro and in Spontaneous Hypertensive Rats

Authors
Lim, Ho-JeongKim, Mi-SoKim, Da-SomKim, Young JunLee, Jin HyupPan, Jeong HoonShin, Eui-CheolKim, Jae Kyeom
Issue Date
7월-2017
Publisher
MARY ANN LIEBERT, INC
Keywords
alcalase; angiotensin-converting enzyme; antihypertensive effect; Camellia japonica; spontaneously hypertensive rat
Citation
JOURNAL OF MEDICINAL FOOD, v.20, no.7, pp.720 - 723
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF MEDICINAL FOOD
Volume
20
Number
7
Start Page
720
End Page
723
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/83039
DOI
10.1089/jmf.2016.0175
ISSN
1096-620X
Abstract
High blood pressure is one of the major risk factors for various diseases and angiotensin-converting enzyme (ACE) plays a critical role in blood pressure regulation. In our study, the responsive surface methodology was adopted to establish optimal Alcalase-hydrolysis conditions of camellia seed hull against ACE activity. The optimum conditions are hydrolysis temperature of 50.98 degrees C, enzyme/substrate ratio of 2.85%, and hydrolysis pH of 7.12. In an animal feeding study, spontaneously hypertensive rats were treated with either a low or high dose of hydrolyzed Camellia japonica seed cake over 5 weeks. Even though systolic blood pressure was not statistically different, the high dose of C. japonica hydrolysate lowered diastolic blood pressure (106 +/- 4.4mmHg vs. 145 +/- 5.9 mmHg) at the 5th week. A similar trend was also observed in serum ACE activity. Considering that this camellia seed hull is a major resource of this plant, our study provides important data to utilize this plant for both academic and industrial applications.
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