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Bacillus licheniformis Isolated from Traditional Korean Food Resources Enhances the Longevity of Caenorhabditis elegans through Serotonin Signaling

Authors
Park, Mi RiOh, SangnamSon, Seok JunPark, Dong-JuneOh, SejongKim, Sae HunJeong, Do-YounOh, Nam SuLee, YoungbokSong, MinhoKim, Younghoon
Issue Date
2-12월-2015
Publisher
AMER CHEMICAL SOC
Keywords
Caenorhabditis elegans; Bacillus licheniformis; serotonin signaling; antiaging; Korean traditional foods
Citation
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.63, no.47, pp.10227 - 10233
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume
63
Number
47
Start Page
10227
End Page
10233
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/91614
DOI
10.1021/acs.jafc.5b03730
ISSN
0021-8561
Abstract
In this study, we investigated potentially probiotic Bacillus licheniformis strains isolated from traditional Korean food sources for ability to enhance longevity using the nematode Caenorhabditis elegans as a simple in vivo animal model. We first investigated whether B. licheniformis strains were capable of modulating the lifespan of C. elegans. Among the tested strains, preconditioning with four B. licheniformis strains significantly enhanced the longevity of C. elegans. Unexpectedly, plate counting and transmission electron microscopy (TEM) results indicated that B. licheniformis strains were not more highly attached to the C. elegans intestine compared with Escherichia coli OP50 or Lactobacillus rhamnosus GG controls. In addition, qRT-PCR and an aging assay with mutant worms showed that the conditioning of B. licheniformis strain 141 directly influenced genes associated with serotonin signaling in nematodes, including tph-1 (tryptophan hydroxylase), bas-1 (serotonin- and dopamine-synthetic aromatic amino acid decarboxylase), mod-1 (serotonin-gated chloride channel), ser-1, and ser-7 (serotonin receptors) during C. elegans aging. Our findings suggest that B. licheniformis strain 141, which is isolated from traditional Korean foods, is a probiotic generally recognized as safe (GRAS) strain that enhances the lifespan of C. elegans via host serotonin signaling.
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