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Effects of Korean Red Ginseng extract on hepatic lipid accumulation in HepG2 cells
- Authors
- Lee, Mak-Soon; Kim, Chong-Tai; Kim, In-Hwan; Kim, Yangha
- Issue Date
- 4-5월-2015
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Korean red ginseng water extract (KRGE); 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase; hepatic lipid accumulation; fatty acid synthase (FAS); HepG2 cells
- Citation
- BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.79, no.5, pp.816 - 819
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
- Volume
- 79
- Number
- 5
- Start Page
- 816
- End Page
- 819
- ISSN
- 0916-8451
- Abstract
- In this study, we investigated the effects of Korean red ginseng water extract (KRGE) on hepatic lipid accumulation in HepG2 cells. KRGE decreased hepatic triglyceride and cholesterol levels. Further, KRGE suppressed expression of fatty acid synthase (FAS) and 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase. These results suggest that KRGE may reduce hepatic lipid accumulation by inhibition of FAS and HMG-CoA reductase expression in HepG2 cells.
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