Effects of Fermented Ginseng Extracts on Tumor Metastasis in Mice
- Authors
- Kang, Dong Zhou; Liu, Dan; Jo, Seon Yoong; Kang, Tae-Bong; Lee, Jin Moo; Suh, Hyung Joo; Kim, Ae-jung; Yoon, Taek Joon
- Issue Date
- Dec-2010
- Publisher
- KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
- Keywords
- fermented-ginseng; tumor metastasis; innate immunity; mucosal immunity; cytokine
- Citation
- FOOD SCIENCE AND BIOTECHNOLOGY, v.19, no.6, pp.1559 - 1565
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- FOOD SCIENCE AND BIOTECHNOLOGY
- Volume
- 19
- Number
- 6
- Start Page
- 1559
- End Page
- 1565
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/115204
- DOI
- 10.1007/s10068-010-0221-9
- ISSN
- 1226-7708
- Abstract
- This study was demonstrated that the fermentation of gingseng increases its biological activities, by comparing the anti-tumor and immunostimulating activities of fermented gingseng extracts (FginE) with those of non-fermented ginseng (GinE). In the experimental lung metastasis of colon26-M3.1 carcinoma, the intraperitoneal (i.p.) or peroral (p.o.) administration of FginE showed stronger anti-tumor metastatic activities than those of GinE. When stimulating 2 kinds of extract on macrophages, FginE was shown to have a higher production of interleukin (IL)-12 than GinE. In addition, treatment with FginE induced tumoricidal activity of peritoneal macrophages against colon26-M3.1 cells. When Peyer's patch was co-cultured with FginE, the proliferation of these cells and granulocyte macrophage-colony stimulating factor (GMCSF) production were induced. In an assay for natural killer (NK) cell activity, an i.p. administration of FginE significantly augmented NK cytotoxicity against Yac-1 tumor cells. Fermented ginseng extracts promotes antitumor activities to inhibit tumor metastasis, and its antitumor effects are associated with the enhancement of systemic as well as mucosal immune systems.
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