Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Effects of Fermented Ginseng Extracts on Tumor Metastasis in Mice

Authors
Kang, Dong ZhouLiu, DanJo, Seon YoongKang, Tae-BongLee, Jin MooSuh, Hyung JooKim, Ae-jungYoon, Taek Joon
Issue Date
Dec-2010
Publisher
KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
Keywords
fermented-ginseng; tumor metastasis; innate immunity; mucosal immunity; cytokine
Citation
FOOD SCIENCE AND BIOTECHNOLOGY, v.19, no.6, pp.1559 - 1565
Indexed
SCIE
SCOPUS
KCI
Journal Title
FOOD SCIENCE AND BIOTECHNOLOGY
Volume
19
Number
6
Start Page
1559
End Page
1565
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/115204
DOI
10.1007/s10068-010-0221-9
ISSN
1226-7708
Abstract
This study was demonstrated that the fermentation of gingseng increases its biological activities, by comparing the anti-tumor and immunostimulating activities of fermented gingseng extracts (FginE) with those of non-fermented ginseng (GinE). In the experimental lung metastasis of colon26-M3.1 carcinoma, the intraperitoneal (i.p.) or peroral (p.o.) administration of FginE showed stronger anti-tumor metastatic activities than those of GinE. When stimulating 2 kinds of extract on macrophages, FginE was shown to have a higher production of interleukin (IL)-12 than GinE. In addition, treatment with FginE induced tumoricidal activity of peritoneal macrophages against colon26-M3.1 cells. When Peyer's patch was co-cultured with FginE, the proliferation of these cells and granulocyte macrophage-colony stimulating factor (GMCSF) production were induced. In an assay for natural killer (NK) cell activity, an i.p. administration of FginE significantly augmented NK cytotoxicity against Yac-1 tumor cells. Fermented ginseng extracts promotes antitumor activities to inhibit tumor metastasis, and its antitumor effects are associated with the enhancement of systemic as well as mucosal immune systems.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Suh, Hyung Joo photo

Suh, Hyung Joo
College of Health Sciences (School of Biosystems and Biomedical Sciences)
Read more

Altmetrics

Total Views & Downloads

BROWSE