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Cruciferous vegetables and colorectal cancer prevention through microRNA regulation: A review

Authors
Pan, Jeong HoonAbernathy, BreannKim, Young JunLee, Jin HyupKim, Jun HoShin, Eui CheolKim, Jae Kyeom
Issue Date
2018
Publisher
TAYLOR & FRANCIS INC
Keywords
Glucosinolates; colorectal cancer; cruciferous vegetables; microRNA
Citation
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, v.58, no.12, pp.2026 - 2038
Indexed
SCIE
SCOPUS
Journal Title
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
Volume
58
Number
12
Start Page
2026
End Page
2038
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/132148
DOI
10.1080/10408398.2017.1300134
ISSN
1040-8398
Abstract
Diets rich in fruits and vegetables may lower colorectal cancer risk. In particular, a number of in vitro and in vivo studies demonstrated that cruciferous vegetables and their active compounds elicit chemopreventive potency through multiple mechanisms. However, it is relatively unexplored whether these vegetables modulate the risk of cancer development through epigenetic mechanisms including noncoding RNAs. Therefore, the objective of the present review is to report and discuss existing evidence with regards to modulation of microRNAs (miRNAs), one variety of noncoding RNAs, by cruciferous vegetables and their chemo-preventive effects against colorectal cancers. As results, it seems clear, considering accumulating evidence regarding their interactions with cancer related genes and relevant signaling pathways, that miRNA modulation via cruciferous vegetables is an attractive target for the prevention of colorectal cancer. In addition, miRNAs have been characterized as diagnostic and prognostic biomarkers and utilized in cancer therapeutics. Thus, it is very possible that natural agents (not limited to those in cruciferous vegetables) enhance cancer therapeutic efficacy and elicit chemopreventive effects through modulating key miRNAs.
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