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Fermented Cordyceps militaris Extract Ameliorates Hepatosteatosis via Activation of Fatty Acid Oxidation

Authors
Nguyen Khoi Song TranKim, Goon-TaeLee, Do YupKim, Young-JunPark, Hye-JinPark, Dong KiPark, Tae-Sik
Issue Date
1-4월-2019
Publisher
MARY ANN LIEBERT, INC
Keywords
fatty acid oxidation; fatty liver; fermentation; sphingosine 1-phosphate; steatosis
Citation
JOURNAL OF MEDICINAL FOOD, v.22, no.4, pp.325 - 336
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF MEDICINAL FOOD
Volume
22
Number
4
Start Page
325
End Page
336
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/66075
DOI
10.1089/jmf.2018.4245
ISSN
1096-620X
Abstract
Nonalcoholic fatty liver disease is a progressive disease involving the accumulation of lipid droplets in the liver. In this study, we investigated the anti-hepatosteatosis effects of fermented Cordyceps militaris extract (CME) in AML-12 hepatocytes. Although the levels of adenosine and cordycepin were reduced in the extracts of CM grown on germinated soybean (GSCE) and fermented CM grown on germinated soybean (GSC) by Pediococcus pentosaceus ON188 (ON188E), the expression of fatty acid oxidation (FAO) genes were upregulated only by GSC-ON188E treatment in a dose-dependent manner. In contrast, a lipogenic gene, stearoyl Coenzyme A desaturase 1, was downregulated by ON188E. Formation of intracellular lipid droplets by the addition of oleic acid was reduced by ON188E to levels observed in WY14643-treated cells. When cells were treated with ON188E, sphingosine kinase 2 mainly responsible for hepatic sphingosine 1-phosphate (S1P) synthesis was upregulated and S1P was elevated. Collectively, the fermented GSC extract activates FAO through elevation of S1P synthesis and has potential as a therapeutic for hepatosteatosis.
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