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Saponin-Based Nanoemulsification Improves the Antioxidant Properties of Vitamin A and E in AML-12 Cells
- Authors
- Choudhry, Qaisra Naheed; Kim, Mi Jeong; Kim, Tae Gyun; Pan, Jeong Hoon; Kim, Jun Ho; Park, Sung Jin; Lee, Jin Hyup; Kim, Young Jun
- Issue Date
- 9월-2016
- Publisher
- MDPI AG
- Keywords
- vitamin A; vitamin E; nanoemulsification; saponin; antioxidant capacity
- Citation
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.17, no.9
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Volume
- 17
- Number
- 9
- ISSN
- 1661-6596
- Abstract
- Our work aimed to investigate the protective effects of saponin-based nanoemulsions of vitamin A and E against oxidative stress-induced cellular damage in AML-12 cells. Saponin nanoemulsions of vitamin A (SAN) and vitamin E (SEN) were prepared by high-pressure homogenization and characterized in terms of size, zeta potential, and polydispersity index. SEN and SAN protect AML-12 cells against oxidative stress-induced cellular damage more efficiently via scavenging reactive oxygen species (ROS), and reducing DNA damage, protein carbonylation, and lipid peroxidation. These results provide valuable information for the development of nanoemulsion-based delivery systems that would improve the antioxidant properties of vitamin A and E.
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Collections - Graduate School > Department of Food and Biotechnology > 1. Journal Articles
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