Zeatin Prevents Amyloid beta-Induced Neurotoxicity and Scopolamine-Induced Cognitive Deficits
- Authors
- Choi, Soo Jung; Jeong, Chang-Ho; Choi, Sung-Gil; Chun, Ji-Yeon; Kim, Young Jun; Lee, JeongMin; Shin, Dong-Hoon; Heo, Ho Jin
- Issue Date
- 4월-2009
- Publisher
- MARY ANN LIEBERT, INC
- Keywords
- neurotoxicity; scopolamine; zeatin
- Citation
- JOURNAL OF MEDICINAL FOOD, v.12, no.2, pp.271 - 277
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF MEDICINAL FOOD
- Volume
- 12
- Number
- 2
- Start Page
- 271
- End Page
- 277
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/120386
- DOI
- 10.1089/jmf.2007.0678
- ISSN
- 1096-620X
- Abstract
- The antioxidative and protective effects of zeatin against amyloid beta-protein (A beta)-induced neurotoxicity were investigated using PC12 cells. Zeatin showed antioxidative and cell protective effects against A beta-induced neurotoxicity. In this study, we also evaluated the effect of zeatin on learning and memory capacity in vivo using ICR mice with amnesia induced by scopolamine (1 mg/kg of body weight). Zeatin, when administered to mice at 4.5 mg/kg of body weight, significantly ameliorated scopolamine-induced amnesia as measured in both the passive avoidance test and Y-maze test. Injecting mice with scopolamine impaired performance on the passive avoidance test (48 +/- 4.5% decrease) and on the Y-maze test (12 +/- 1.3% decrease). In contrast, mice treated with zeatin before scopolamine injections were protected from these changes (5-34% decrease in step-through latency; 1-4% decrease in alternation behavior). The present results suggest a possible chemopreventive role of zeatin in Alzheimer's disease.
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Collections - Graduate School > Department of Food and Biotechnology > 1. Journal Articles
- College of Science and Technology > Department of Food and Biotechnology > 1. Journal Articles
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